If you watch House when he either enters or leaves his home, you will see that the address is: 221B. This references the greatest detective ever. Mr Sherlock Holmes of 221B baker street. I'm not sure yet what street he lives on, but I'll keep looking.
David Shore has said the entire character concept of House is based on Sherlock Homes, in particular his remarkable ability to rapidly deduce characteristics and past actions of a person simply by giving them a once-over.
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