Invader ZIM Easter Egg - Ms. Bitters

If you watch Invader Zim, then you must know about Ms. Bitters, Zim's teacher. If you are a fan of Jhonen Vasquez's comics Squee (The main character is taken from Johnny the Homocidal Maniac), then you have probably seen Squee's teacher... Does she look familiar? Its Ms. Bitters!