Towards the end of the episode "Germs" when Zim and GIR go into MacMeaties, Zim notices that the meat does not have any germs. Pay attention when he runs around and checks other people's burgers. You can see a skinny man with red hair and glasses sitting in a booth across from a heavier man with a beard also wearing glasses. The skinny man is the creator of the show, Jhonen Vasquez, and the other man is the director, Steve Ressel. Sitting on the table between them is a script titled "The Nightmare Begins" which is the title of the first episode of the show.